ST. CHARLES, Mo.—A crash in eastern Missouri Friday claims the lives of four Louisville, Kentucky residents.

Troop C records show, a three-vehicle-crash in St. Charles County, along I-64, occurred when the eastbound vehicle driven by Elijah C. Henderson, of Saint Charles, traveled off the roadway and through the barrier cable, before colliding head-on with two vehicles. Professionals pronounced the driver of a westbound vehicle, Lesley D. Prather and a 12-year-old passenger, dead at the scene. Prather’s two other passengers, Carrie R. McCaw and another 12-year-old, died at area hospitals. Henderson sought treatment of serious injuries. The driver of another westbound vehicle involved, an Illinois resident, remained unharmed.